Let's experiment, explore the unknowns and prepare to be surprised by unexpected results and to be open to evaluate all the possible explanations - Or we will possibly miss even our own maybe fortuitous discoveries and inventions.
Perhaps the only thing better for a scientist than finding the crucial piece of a puzzle that completes a picture is finding a piece that doesn't fit at all, and tells us that there is a whole new part of the puzzle that we haven't even imagined yet and the scene in the puzzle is bigger, richer than we ever thought.
From Saul Perlmutter's speech at the Nobel Banquet, 10 December 2011